This is where most of the commercial claims live, and where the picture gets genuinely uncomfortable.
Knee osteoarthritis — a real effect, very low certainty
A 2024 systematic review with meta-analysis in Physical Therapy pooled ten placebo-controlled trials of 542 participants. Pain at rest improved significantly against placebo — a moderate effect — but the authors graded the certainty of evidence as very low, judged all included studies at unclear to high risk of bias, found no significant effect on the Timed Up and Go test, and concluded that isolated use cannot be recommended (PMID 38775202).
Then there is the trial that tested the question operators actually care about. A six-month double-blind placebo-controlled RCT in the Brazilian Journal of Physical Therapy randomised 127 knee osteoarthritis patients to exercise, exercise plus active photobiomodulation, or exercise plus placebo photobiomodulation. Everyone improved substantially. There was no difference between groups at any follow-up (PMID 37572382).
Read together: light may beat nothing, and does not appear to beat exercise or add to it. That is a very different sales proposition.
Low back pain — a clean negative
A systematic review in the Journal of Physiotherapy in 2020 pooled twelve randomised trials, 1,046 participants, most at low risk of bias, and concluded that the effect of photobiomodulation on pain and disability against sham was clinically unimportant in both acute and chronic non-specific low back pain, and no better than exercise (PMID 32680739). Low back pain is one of the most common reasons people buy a panel. The evidence says do not.
Athletic recovery and performance
Active research area, genuinely mixed results, protocols too heterogeneous to pool cleanly. If recovery is the goal, the evidence base behind contrast therapy, sauna recovery and cold immersion is currently stronger and cheaper to install.